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Alzheimer's Disease Risk & Cognitive Decline Panel

Early detection of Alzheimer's disease is possible years before symptoms begin. Our comprehensive panel combines genetic, molecular, and biomarker analysis with reversible cause screening — empowering you and your clinician to take proactive steps against cognitive decline.

Alzheimer’s Disease Risk & Cognitive Decline Panel

Genetic Risk Marker

  • APOE Genotype
    • ε4 allele increases risk of late-onset Alzheimer’s disease.
    • Useful for risk stratification and counseling, but not deterministic.

ATN Profile (Core Alzheimer’s Biomarkers)

  • A = Amyloid
    • Aβ42, Aβ40, and Aβ42/40 ratio (plasma or CSF)
    • Low ratio suggests amyloid accumulation.
  • T = Tau
    • p-tau181 (or p-tau217, p-tau231 if available)
    • Elevated levels are highly specific for Alzheimer’s pathology.
  • N = Neurodegeneration
    • NfL (Neurofilament Light Chain)
    • MRI volumetrics (hippocampal atrophy) or FDG-PET optional.

Reversible / Secondary Causes of Cognitive Impairment

  • Thyroid
    • TSH (hypothyroidism can mimic dementia).
  • Infectious
    • RPR (syphilis serology).
    • Lyme antibody panel (Borrelia infection can cause cognitive issues).
    • ANA (antinuclear antibody) — screens for autoimmune/inflammatory causes.
  • Nutritional / Metabolic
    • B12
    • Methylmalonic Acid (MMA) — more sensitive indicator of functional B12 deficiency.
    • ESR (Sedimentation Rate) — marker of systemic inflammation.

Clinical Use

  • Baseline risk stratification: APOE + ATN profile.
  • Rule out treatable causes: thyroid, B12, infections, autoimmune.
  • Guide intervention: tailor prevention (lifestyle, vascular risk control, supplements, clinical trial eligibility).

Detect Early Changes with the ATN Framework

Amyloid brain scan

A (Amyloid)

Aβ42, Aβ40, Aβ42/40 ratio

Low ratio indicates amyloid accumulation

Tau brain scan

T (Tau)

p-tau181 (or p-tau217/p-tau231)

Elevated levels signal Alzheimer's-specific pathology.

Neurodegeneration brain scan

N (Neurodegeneration)

Neurofilament Light Chain (NfL), MRI volumetrics, FDG-PET

Indicates neuronal injury and structural loss.

Rule Out Treatable Causes of Cognitive Decline

Thyroid

  • bulletTSH – screens for hypothyroidism

Infectious

  • bulletRPR – syphilis
  • bulletLyme antibody panel
  • bulletANA – autoimmune causes

Nutritional / Metabolic

  • bulletVitamin B12
  • bulletMMA – functional B12 deficiency
  • bulletESR – inflammation marker

Clinical Utility

Clinical Checklist

How This Panel Helps You

  • bulletBaseline risk assessment (APOE + ATN)
  • bulletIdentify treatable causes
  • bulletGuide personalized prevention strategies
  • bulletInform clinical trial eligibility